Description

1-(Trifluoromethyl)Vinyl Boronic Acid Hexylene Glycol Ester is a high-value, protected boronic acid ester derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling the efficient and selective introduction of the versatile 1-(trifluoromethyl)vinyl group into complex molecules via cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it facilitates the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing carbon-carbon bonds in drug discovery and development, particularly for incorporating the metabolically stable trifluoromethyl group.
• Agrochemical Synthesis: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl moiety enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.
• Advanced Material Precursor: Employed in the synthesis of organic electronic materials, liquid crystals, and polymers requiring specific fluorine-containing functional groups for tailored properties.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems, leveraging the unique properties of the boron and fluorine atoms.
• Custom & Contract Synthesis: A critical starting material for custom synthesis houses and CROs (Contract Research Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(Trifluoromethyl)Vinyl Boronic Acid Hexylene Glycol Ester
CAS No.	1011460-68-6
Molecular Formula	C11H18BF3O2
Molecular Weight	250.07 g/mol
Synonyms	1-(Trifluoromethyl)ethenylboronic acid hexylene glycol ester; 2-(1-Trifluoromethylvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (1-Trifluoromethylvinyl)boronic acid pinacol ester; 1-(Trifluoromethyl)vinylboronic acid pinacol ester; 2-[1-(Trifluoromethyl)vinyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-Trifluoromethylvinylboronic Acid Pinanediol Ester (common trade name variant); B-[1-(Trifluoromethyl)ethenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 1-(Trifluoromethyl)Vinyl Boronic Acid Hexylene Glycol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques including NMR (¹H, ¹³C, ¹¹B, ¹⁹F), HPLC, and GC to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Handle and store away from strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%
NMR Purity (¹H)	≥95%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.