Description

2-Carboxythiophene-4-Boronic Acid Pinacol Ester is a high-value, multifunctional heterocyclic building block essential for modern synthetic chemistry. This compound matters because it combines a reactive boronic ester group with a carboxylic acid functionality, enabling sequential cross-coupling and derivatization reactions in a single molecule. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and advanced organic electronic materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel drug candidates, especially those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific thiophene-based scaffolds.
• Organic Electronic Materials: Serves as a building block for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Ligand and Catalyst Development: The carboxylic acid group allows for easy conversion into amides or esters, facilitating the creation of novel ligands for catalysis.
• Chemical Biology & Probe Design: Utilized in the synthesis of molecular probes and tags for studying biological systems due to its bifunctional reactivity.
• Polymer Chemistry: Can be incorporated as a monomer or end-group modifier to introduce functionality into polymer chains.

Basic Information

Product Name	2-Carboxythiophene-4-Boronic Acid Pinacol Ester
CAS No.	1010836-19-7
Molecular Formula	C₁₂H₁₇BO₄S
Molecular Weight	268.14 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylic Acid; 2-Thiophenecarboxylic Acid, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(Pinacolatoboryl)thiophene-2-carboxylic Acid; 4-Borono-2-thiophenecarboxylic Acid Pinacol Ester; Thiophene-4-boronic Acid Pinacol Ester, 2-carboxy-; 2-Carboxy-4-thienylboronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Every batch of 2-Carboxythiophene-4-Boronic Acid Pinacol Ester undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and scale-up applications. Our quality assurance protocol includes identity confirmation, purity assessment, and impurity profiling. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.