Description

2',5'-Difluoro-4'-Methoxyacetophenone is a high-purity fluorinated acetophenone derivative, a key building block in advanced organic synthesis. Its value lies in its precise molecular structure, which is engineered to introduce specific fluorine and methoxy substituents into target molecules, enabling the development of compounds with enhanced biological activity and metabolic stability. This intermediate is critically needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting new therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex drug candidates, especially those requiring fluorinated aromatic motifs for improved potency and pharmacokinetic properties.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, where the difluoro-methoxy pattern can contribute to enhanced activity and selectivity.
• Material Science Research: Serves as a specialized monomer or building block for developing novel fluorinated polymers and advanced organic materials with unique electronic or surface properties.
• Ligand and Catalyst Development: Employed in the creation of sophisticated ligands for catalysis or as a scaffold in metal-organic frameworks (MOFs) for research applications.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions in API manufacturing.

Basic Information

Product Name	2',5'-Difluoro-4'-Methoxyacetophenone
CAS No.	1010800-85-7
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	1-(2,5-Difluoro-4-methoxyphenyl)ethan-1-one; 2,5-Difluoro-4-methoxyacetophenone; 4'-Methoxy-2',5'-difluoroacetophenone; Ethanone, 1-(2,5-difluoro-4-methoxyphenyl)-; Acetophenone, 2',5'-difluoro-4'-methoxy-; DFMA
EINECS	Contact for details

Quality Control

Every batch of 2',5'-Difluoro-4'-Methoxyacetophenone is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.