Description

3-[2-(5,6,7,8-Tetrahydro-5,5,8,8-Tetramethyl-2-Naphthalenyl)Ethynyl]Benzoic Acid is a high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound, with CAS number 1010694-08-2, is valued for its unique molecular scaffold, which serves as a critical building block in the synthesis of novel therapeutic agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for creating targeted molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel Retinoid X Receptor (RXR) modulators and other nuclear receptor-targeting drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Process Chemistry Development: Serves as a critical starting material or advanced intermediate in scaling up API (Active Pharmaceutical Ingredient) synthesis.
• Biochemical Tool Compound: Potential use in developing probes for studying receptor-ligand interactions and cellular signaling pathways.
• Fine Chemical Synthesis: Intermediate for creating complex, high-value specialty chemicals with specific chiral or steric properties.

Basic Information

Product Name	3-[2-(5,6,7,8-Tetrahydro-5,5,8,8-Tetramethyl-2-Naphthalenyl)Ethynyl]Benzoic Acid
CAS No.	1010694-08-2
Molecular Formula	C25H26O2
Molecular Weight	358.48 g/mol
Synonyms	AGN 194204; 3-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid; Benzoic acid, 3-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)ethynyl]-; RXR Antagonist AGN 194204; AGN-194204; 3-(2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethynyl)benzoic acid
EINECS	Contact for details

Quality Control

Our production of 3-[2-(5,6,7,8-Tetrahydro-5,5,8,8-Tetramethyl-2-Naphthalenyl)Ethynyl]Benzoic Acid adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.