Description

1,3,2-Dioxaborolane, 2-(2,2-Difluoro-1-Phenylcyclopropyl)-4,4,5,5-Tetramethyl- is a high-value, organoboron building block featuring a unique difluorocyclopropyl group. This compound is critical for introducing the difluorocyclopropane moiety into complex molecules, a structural motif known to enhance metabolic stability and binding affinity in pharmaceuticals. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced synthetic applications, including Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the difluorocyclopropane unit can improve biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of advanced polymers and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: An essential boronic ester reagent for palladium-catalyzed carbon-carbon bond formation to create biaryl and other complex aromatic structures.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship exploration by providing a versatile handle for introducing fluorinated cyclopropane rings into lead compounds.
• Fluorine Chemistry: A valuable reagent for studying the effects of gem-difluorocyclopropanation on molecular conformation and physicochemical properties.

Basic Information

Item	Details
Product Name	1,3,2-Dioxaborolane, 2-(2,2-Difluoro-1-Phenylcyclopropyl)-4,4,5,5-Tetramethyl-
CAS No.	1010689-64-1
Molecular Formula	C15H19BF2O2
Molecular Weight	280.12 g/mol
Synonyms	2-(2,2-Difluoro-1-phenylcyclopropyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2,2-Difluoro-1-phenylcyclopropyl)boronic acid pinacol ester; 1-Phenyl-2,2-difluorocyclopropane-1-boronic acid pinacol ester; Difluorocyclopropylphenylboronic acid pinacol ester; 1010689-64-1; Boronic acid, B-(2,2-difluoro-1-phenylcyclopropyl)-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our production of this advanced boronic ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized by NMR (¹H, ¹³C, ¹⁹F), HPLC for purity assessment, and mass spectrometry for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.