Description

1-(4-Methyl-1-Piperazinyl)-2-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-Ethanone is a high-value, advanced pharmaceutical intermediate featuring a key boronic ester pinacol group, making it a crucial building block for modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures essential in drug discovery. This compound is specifically designed for use by pharmaceutical R&D teams and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those requiring complex biaryl or heterobiaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile boronic ester coupling partner for palladium-catalyzed carbon-carbon bond formation with aryl halides or triflates.
• Kinase Inhibitor Development: Used in the research and production of targeted kinase inhibitors, a major class of oncology and anti-inflammatory drugs.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in constructing bifunctional molecules for targeted protein degradation research.
• Material Science Research: Potential building block for creating organic electronic materials and advanced polymers with specific optical or electronic properties.
• Agrochemical Synthesis: Intermediate in the development of new generation herbicides and fungicides with improved efficacy.

Basic Information

Item	Details
Product Name	1-(4-Methyl-1-Piperazinyl)-2-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-Ethanone
CAS No.	1010104-30-9
Molecular Formula	C19H29BN2O3
Molecular Weight	344.26 g/mol
Synonyms	4'-(4-Methylpiperazine-1-carbonyl)phenylboronic acid pinacol ester; 1-(4-Methylpiperazin-1-yl)-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethan-1-one; [4-(4-Methyl-1-piperazinyl)carbonyl]phenylboronic acid pinacol ester; 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-(4-methyl-1-piperazinyl)ethanone; 4-(4-Methylpiperazine-1-carbonyl)benzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our standard pharmaceutical-grade material is validated by multiple orthogonal techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support development and commercial projects requiring compliance with ICH Q7 guidelines and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For long-term stability, store at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.