Description

6-Chloro-5-Methylpyridine-3-Boronic Acid, Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: Critical for synthesizing novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile reagent for academic and industrial labs exploring new C-C bond formation methodologies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and scaled-up API synthesis.

Basic Information

Product Name	6-Chloro-5-Methylpyridine-3-Boronic Acid, Pinacol Ester
CAS No.	1010101-07-1
Molecular Formula	C12H17BClNO2
Molecular Weight	253.53 g/mol
Synonyms	(6-Chloro-5-methylpyridin-3-yl)boronic acid pinacol ester; 5-Methyl-6-chloropyridine-3-boronic acid pinacol ester; 3-Boronic acid, 6-chloro-5-methylpyridine-, pinacol ester; 6-Chloro-5-methyl-3-pyridineboronic acid pinacol ester; Pinacol (6-chloro-5-methylpyridin-3-yl)boronate; (6-Chloro-5-methyl-3-pyridinyl)boronic acid pinacol ester; Boronic acid, B-(6-chloro-5-methyl-3-pyridinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Methylpyridine-3-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.