Description

2-Chloro-3-Methylpyridine-4-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures. CAS No. 1010101-06-0.

Application

• Pharmaceutical Intermediate: A key synthon for constructing novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the pyridine scaffold for bioactivity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other transition metal-catalyzed processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its functionalized heterocyclic structure.
• Chemical Biology Probes: Utilized for tagging and modifying biomolecules, aiding in proteomics and diagnostic assay development.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Item	Detail
Product Name	2-Chloro-3-Methylpyridine-4-Boronic Acid Pinacol Ester
CAS No.	1010101-06-0
Molecular Formula	C₁₂H₁₇BClNO₂
Molecular Weight	253.53 g/mol
Synonyms	2-Chloro-3-methylpyridine-4-boronic acid pinacol ester; (2-Chloro-3-methylpyridin-4-yl)boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-3-methylpyridine; 2-Chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Boronic acid, B-(2-chloro-3-methyl-4-pyridinyl)-, 1,1-dimethylethyl ester; Pinacol (2-chloro-3-methylpyridin-4-yl)boronate
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Methylpyridine-4-Boronic Acid Pinacol Ester undergoes rigorous analytical testing to ensure it meets the stringent requirements of research and development. Our quality assurance protocol includes identity confirmation by NMR and IR spectroscopy and purity assessment via HPLC (typically ≥95% to ≥98%). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0% (Typical: ≥97.0%)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.