Description

6-Chloropyrazine-2-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound matters because it serves as a critical intermediate in the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex heterocyclic systems. Pharmaceutical, agrochemical, and advanced materials researchers need it for the development of new active ingredients and functional molecules. Its stability as a pinacol ester offers superior handling and storage characteristics compared to the free boronic acid.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly those containing chloropyrazine motifs for oncology and CNS applications.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Employed in the creation of organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Research: A versatile reagent for academic and industrial R&D in cross-coupling methodologies and heterocycle functionalization.
• Ligand Synthesis: Precursor for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Scale-Up Production: Suitable for process chemistry and pilot-scale synthesis under GMP-like conditions for advanced projects.

Basic Information

Product Name	6-Chloropyrazine-2-Boronic Acid Pinacol Ester
CAS No.	1009378-52-2
Molecular Formula	C10H14BClN2O2
Molecular Weight	240.50 g/mol
Synonyms	2-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine; (6-Chloropyrazin-2-yl)boronic acid pinacol ester; 6-Chloro-2-pyrazineboronic acid pinacol ester; 2-Chloro-6-(pinacolboranyl)pyrazine; 6-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine; Pinacol (6-chloropyrazin-2-yl)boronate; 6-Chloropyrazine-2-boronic acid, pinacol ester
EINECS	Contact for details

Quality Control

Our 6-Chloropyrazine-2-Boronic Acid Pinacol Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development and production needs with specifications that can meet pharmaceutical intermediate and research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.