Description

7-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Quinazolin-4-One is a high-value, advanced pharmaceutical intermediate featuring a quinazolinone core with a boronic ester protecting group. This compound is critical for enabling efficient cross-coupling reactions, particularly in the synthesis of complex molecules for drug discovery and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the creation of kinase inhibitors and other targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting protein kinases.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester moiety serves as a crucial handle for forming carbon-carbon bonds, enabling the construction of complex biaryl structures common in active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic compounds.
• Chemical Biology Probes: Employed in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals.

Basic Information

Product Name	7-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Quinazolin-4-One
CAS No.	1009303-80-3
Molecular Formula	C₁₄H₁₇BN₂O₃
Molecular Weight	272.11 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-quinazolin-4-one; 7-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-4(1H)-quinazolinone; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4(1H)-quinazolinone; 7-Boronic acid, 4(1H)-quinazolinone, pinacol ester; 7-(Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4(1H)-one; Quinazolin-4(1H)-one, 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 7-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Quinazolin-4-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.