Description

1-Boc-3-Methylpyrazole-4-Boronic Acid Pinacol Ester is a high-purity, protected boronic acid ester building block essential for modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds in pharmaceutical and agrochemical research. This compound is specifically designed for medicinal chemists and process R&D scientists developing novel active ingredients, particularly in the areas of small molecule drug discovery and advanced material synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing functionalized pyrazole heterocycles.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical coupling partner for introducing the 3-methylpyrazole moiety into complex molecular architectures under mild conditions.
• Medicinal Chemistry & Lead Optimization: Used extensively in parallel and combinatorial chemistry for creating focused libraries to explore structure-activity relationships (SAR).
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides that utilize pyrazole-based scaffolds.
• Material Science: Potential precursor for creating organic electronic materials and metal-organic frameworks (MOFs) with specific functional properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	1-Boc-3-Methylpyrazole-4-Boronic Acid Pinacol Ester
CAS No.	1009071-34-4
Molecular Formula	C15H25BN2O4
Molecular Weight	308.18 g/mol
Synonyms	1-Boc-3-methyl-1H-pyrazole-4-boronic acid pinacol ester; tert-Butyl 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate; 3-Methyl-1-((tert-butoxy)carbonyl)-1H-pyrazole-4-boronic acid pinacol ester; 1-(tert-Butoxycarbonyl)-3-methyl-1H-pyrazole-4-boronic acid pinacol ester; Boc-3-Me-Pyrazole-4-Bpin; 1-Boc-3-Me-Pz-4-Bpin; 1-Boc-3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
EINECS	Contact for details

Quality Control

Our 1-Boc-3-Methylpyrazole-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the rigorous demands of research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, and custom synthesis and purification to meet specific client specifications (e.g., >98%, >99% HPLC purity) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the container under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C. The compound is light-sensitive and easily oxidized; allow the sealed container to reach room temperature before opening to minimize moisture condensation and oxidative degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Typical: 98-99%)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.