Description

2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid is a high-value boronic ester derivative of a difluorobenzoic acid, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling the efficient construction of complex molecules through reliable cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require precise, functionalized intermediates for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing a difluorophenyl moiety.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester group makes it an ideal, air-stable reagent for palladium-catalyzed carbon-carbon bond formation.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic routes and creating compound libraries for screening.
• Ligand and Catalyst Preparation: Useful for synthesizing complex ligands and organometallic catalysts used in asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid
CAS No.	1008119-07-0
Molecular Formula	C13H15BF2O4
Molecular Weight	284.07 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-difluorobenzoic Acid; 2,6-Difluoro-4-(pinacolboronyl)benzoic Acid; 2,6-Difluoro-4-(pinacolatoboron)benzoic Acid; 4-Borono-2,6-difluorobenzoic Acid Pinacol Ester; 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenecarboxylic Acid; 2,6-Difluoro-4-pinacolboronobenzoic Acid; CAS 1008119-07-0
EINECS	Contact for details

Quality Control

Our production of 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.