Description

1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidin-2-One is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting neurological disorders and cancer.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aromatic rings, essential for creating diverse chemical libraries for high-throughput screening.
• Organic Synthesis Research: Used in academic and industrial R&D labs for methodological development and the construction of complex organic molecules.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands or catalysts used in asymmetric synthesis.
• Material Science Exploration: Potential use in the synthesis of organic electronic materials and polymers due to its aromatic and boronate ester functionality.

Basic Information

Product Name	1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidin-2-One
CAS No.	1007346-42-0
Molecular Formula	C17H24BNO3
Molecular Weight	301.19 g/mol
Synonyms	2-(4-(2-Oxopiperidin-1-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidin-2-one; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-piperidinone; 4,4,5,5-Tetramethyl-2-[4-(2-oxo-1-piperidinyl)phenyl]-1,3,2-dioxaborolane; 1-(4-Pinacolatoborylphenyl)piperidin-2-one
EINECS	Contact for details

Quality Control

Our production of 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidin-2-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and LC-MS. We support compliance with cGMP and ISO 9001 standards for research-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture and atmospheric oxygen, which can affect the stability of the boronate ester group.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.