Description

4'-Bromo-2',3'-Difluoroacetophenone CAS NO 1007346-28-2 is a high-purity, multi-functional fluorinated aromatic ketone building block essential for advanced organic synthesis. This compound is valued for its unique halogenated and fluorinated structure, which enables precise molecular modifications in complex chemical architectures. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic motifs.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the difluoro and bromo substituents confer specific biological activity.
• Material Science Research: Serves as a building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings.
• Fluorine Chemistry Studies: An important reagent for investigating the effects of ortho- and meta-fluorine substitution on aromatic system reactivity and physical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates for client-specific drug discovery programs.

Basic Information

Product Name	4'-Bromo-2',3'-Difluoroacetophenone
CAS No.	1007346-28-2
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	1-(4-Bromo-2,3-difluorophenyl)ethanone; 4-Bromo-2,3-difluoroacetophenone; 2',3'-Difluoro-4'-bromoacetophenone; 4'-Bromo-2',3'-difluoroacetophenone; 1-(4-Bromo-2,3-difluorophenyl)ethan-1-one; Ethanone, 1-(4-bromo-2,3-difluorophenyl)-; Acetophenone, 4'-bromo-2',3'-difluoro-
EINECS	Contact for details

Quality Control

Our 4'-Bromo-2',3'-Difluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports applications in regulated environments, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases, reducing agents, and heat sources. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.