Description

cis-3-Boc-Amino-Tetrahydropyran-4-Carboxylic Acid is a high-purity, protected amino acid derivative featuring a tetrahydropyran scaffold and a tert-butoxycarbonyl (Boc) protecting group. This compound serves as a critical chiral building block in the synthesis of complex pharmaceutical molecules, offering precise stereochemical control. It is primarily utilized by research and development chemists and process development teams in the pharmaceutical and biotechnology industries for the creation of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and metabolic disease targets.
• Peptidomimetic Synthesis: Used to incorporate constrained, non-natural amino acid motifs into peptide backbones to enhance metabolic stability and bioavailability.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel chemical space.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scalable synthesis of target molecules under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology: Utilized as a probe or tool compound for studying biological pathways and protein-ligand interactions.
• Custom Synthesis: A foundational component for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.

Basic Information

Product Name	cis-3-Boc-Amino-Tetrahydropyran-4-Carboxylic Acid
CAS No.	1006891-33-3
Molecular Formula	C11H19NO5
Molecular Weight	245.27 g/mol
Synonyms	(3R,4S)-1-Boc-3-amino-4-carboxytetrahydro-2H-pyran; (3R,4S)-3-[(tert-Butoxycarbonyl)amino]tetrahydro-2H-pyran-4-carboxylic acid; cis-3-[(tert-Butoxycarbonyl)amino]tetrahydropyran-4-carboxylic acid; (3R,4S)-3-(Boc-amino)tetrahydropyran-4-carboxylic acid; Boc-cis-3-amino-THP-4-carboxylic acid; cis-3-N-Boc-Amino-4-carboxytetrahydro-2H-pyran; Boc-Aze-OH(4-cis) (common abbreviation); 1-Boc-3-amino-4-carboxytetrahydro-2H-pyran (cis)
EINECS	Contact for details

Quality Control

Our cis-3-Boc-Amino-Tetrahydropyran-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.