Description

(Trans)-2-(3,4-Difluorophenyl)Cyclopropanecarboxamide is a high-purity, advanced pharmaceutical intermediate featuring a cyclopropane ring and a difluorophenyl moiety. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific stereochemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, agrochemicals, and other fine chemicals. Our supply ensures consistent quality and reliable availability for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Serves as a precursor in the creation of novel pesticides and herbicides, leveraging the biological activity of the difluorophenyl group.
• Chemical Research: Used in academic and industrial laboratories for method development, catalysis studies, and exploring new chemical entities.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of target molecules in fine chemical manufacturing.
• Ligand and Catalyst Development: The rigid cyclopropane structure makes it a candidate for developing novel chiral ligands and organocatalysts.

Basic Information

Product Name	(Trans)-2-(3,4-Difluorophenyl)Cyclopropanecarboxamide
CAS No.	1006614-51-2
Molecular Formula	C10H9F2NO
Molecular Weight	197.18 g/mol
Synonyms	trans-2-(3,4-Difluorophenyl)cyclopropanecarboxamide; (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide (enantiomer); (1S,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide (enantiomer); 2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid amide; 3,4-Difluoro-trans-cyclopropanecarboxanilide; Cyclopropanecarboxamide, 2-(3,4-difluorophenyl)-, trans-; (Trans)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid amide
EINECS	Contact for details

Quality Control

Our (Trans)-2-(3,4-Difluorophenyl)Cyclopropanecarboxamide is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay, chiral purity, and impurity profiles. Our quality commitment supports applications requiring GMP-grade materials for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.