Description

trans-2-(3,4-Difluorophenyl) Cyclopropanecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclopropane ring and difluorophenyl substitution. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and target selectivity. It is primarily utilized by research institutions and pharmaceutical manufacturers developing next-generation therapeutics in areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel small-molecule drug candidates.
• API Synthesis: Serves as a crucial precursor in the multi-step synthesis of complex target molecules, particularly in oncology and CNS drug pipelines.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its rigid cyclopropane scaffold and fluorine atoms, which can improve potency and pharmacokinetic properties.
• Agrochemical Intermediates: Potential application in the synthesis of advanced crop protection agents, leveraging the biological activity of the difluorophenyl moiety.
• Material Science Precursor: Can be investigated for the synthesis of specialized monomers or ligands for advanced polymeric or coordination compounds.

Basic Information

Product Name	trans-2-(3,4-Difluorophenyl) Cyclopropanecarboxylic Acid
CAS No.	1006614-50-1
Molecular Formula	C10H8F2O2
Molecular Weight	198.17 g/mol
Synonyms	(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic Acid; (1S,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic Acid; trans-2-(3,4-Difluorophenyl)cyclopropanecarboxylic Acid; 2-(3,4-Difluorophenyl)cyclopropanecarboxylic Acid; 1006614-50-1; Cyclopropanecarboxylic acid, 2-(3,4-difluorophenyl)-, trans-; 3,4-Difluorophenylcyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our trans-2-(3,4-Difluorophenyl) Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.