Description

3-Cyclopropyl-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid is a high-value pyrazole carboxylic acid derivative, distinguished by its cyclopropyl and trifluoroethyl substituents which impart unique steric and electronic properties. This compound is a critical pharmaceutical intermediate for the synthesis of advanced active ingredients, particularly in therapeutic areas requiring targeted bioactivity. It is essential for R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with enhanced efficacy.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Research: Serves as a precursor for developing new-generation herbicides and fungicides with improved selectivity and environmental profiles.
• Ligand Synthesis: Used in organometallic chemistry and catalysis to create specialized ligands for transition metal complexes.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Material Science: A potential monomer or additive for creating specialty polymers with specific fluorinated characteristics.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Product Name	3-Cyclopropyl-1-(2,2,2-Trifluoroethyl)-1H-Pyrazole-4-Carboxylic Acid
CAS No.	1006486-60-7
Molecular Formula	C9H9F3N2O2
Molecular Weight	234.18 g/mol
Synonyms	1H-Pyrazole-4-carboxylic acid, 3-cyclopropyl-1-(2,2,2-trifluoroethyl)-; 3-Cyclopropyl-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid; 3-Cyclopropyl-1-(trifluoroethyl)pyrazole-4-carboxylic acid; 4-Carboxy-3-cyclopropyl-1-(2,2,2-trifluoroethyl)pyrazole; 1006486-60-7
EINECS	Contact for details

Quality Control

Our production of 3-Cyclopropyl-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support development and commercial projects requiring material produced under GMP-like controls for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.