Description

1-(2,2-Difluoroethyl)-3-(Trifluoromethyl)-1H-Pyrazole-5-Carboxylic Acid is a high-value, multi-fluorinated pyrazole derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both difluoroethyl and trifluoromethyl groups, makes it an essential intermediate for introducing fluorine atoms into target molecules, thereby modulating their physicochemical and biological properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases, oncology, and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where fluorination enhances lipophilicity, metabolic stability, and binding affinity.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials that benefit from the unique electronic properties of fluorine.
• Chemical Biology Probes: Serves as a precursor for fluorinated probes and tags used in bioimaging and mechanistic studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	1-(2,2-Difluoroethyl)-3-(Trifluoromethyl)-1H-Pyrazole-5-Carboxylic Acid
CAS No.	1006462-23-2
Molecular Formula	C7H5F5N2O2
Molecular Weight	244.12 g/mol
Synonyms	5-Carboxy-1-(2,2-difluoroethyl)-3-(trifluoromethyl)-1H-pyrazole; 1H-Pyrazole-5-carboxylic acid, 1-(2,2-difluoroethyl)-3-(trifluoromethyl)-; 1-(2,2-Difluoroethyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid; 3-(Trifluoromethyl)-1-(2,2-difluoroethyl)-1H-pyrazole-5-carboxylic acid; Difluoroethyl Trifluoromethyl Pyrazole Carboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 1-(2,2-Difluoroethyl)-3-(Trifluoromethyl)-1H-Pyrazole-5-Carboxylic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and scale-up applications. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.