Description

1-(2,2,2-Trifluoroethyl)-1H-Pyrazole-5-Carboxylic Acid is a high-value trifluoromethylated pyrazole derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise introduction of the trifluoroethyl group, a key structural motif known to dramatically enhance the metabolic stability, lipophilicity, and bioavailability of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients. The CAS number for this compound is 1006340-71-1.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoroethyl group can improve environmental stability and efficacy.
• Material Science Research: Employed as a precursor for synthesizing specialty polymers, liquid crystals, or organic electronic materials that benefit from fluorine incorporation.
• Chemical Biology & Probe Development: Serves as a versatile scaffold for creating molecular probes and bio-conjugation reagents used in diagnostic and biochemical research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(2,2,2-Trifluoroethyl)-1H-Pyrazole-5-Carboxylic Acid
CAS No.	1006340-71-1
Molecular Formula	C6H5F3N2O2
Molecular Weight	194.11 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)-1H-pyrazole-5-carboxylic acid; 1H-Pyrazole-5-carboxylic acid, 1-(2,2,2-trifluoroethyl)-; 5-Carboxy-1-(2,2,2-trifluoroethyl)pyrazole; 1-Trifluoroethylpyrazole-5-carboxylic acid; TFEPCA; 1006340-71-1 (CAS); 1-(Trifluoroethyl)-1H-pyrazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(2,2,2-Trifluoroethyl)-1H-Pyrazole-5-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for use in GMP-oriented research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.