Description

(1S)-2-Methyl-1-[4-(Trifluoromethyl)Phenyl]Propylamine CAS NO 1003887-72-6 is a chiral amine building block featuring a trifluoromethylphenyl group, a structural motif of significant interest in modern synthetic chemistry. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals, where its stereochemistry and fluorine content can critically influence biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced properties.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group improves lipophilicity and bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials with unique electronic properties.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	(1S)-2-Methyl-1-[4-(Trifluoromethyl)Phenyl]Propylamine
CAS No.	1003887-72-6
Molecular Formula	C11H14F3N
Molecular Weight	217.23 g/mol
Synonyms	(1S)-1-[4-(Trifluoromethyl)phenyl]-2-methylpropylamine; (S)-1-(4-(Trifluoromethyl)phenyl)-2-methylpropan-1-amine; (S)-α-Methyl-4-(trifluoromethyl)benzenepropanamine; (S)-2-Methyl-1-[4-(trifluoromethyl)phenyl]propan-1-amine; (S)-1-(4-Trifluoromethylphenyl)-2-methylpropylamine; (S)-TMPPA; Benzenepropanamine, α-methyl-4-(trifluoromethyl)-, (αS)-
EINECS	Contact for details

Quality Control

Our (1S)-2-Methyl-1-[4-(Trifluoromethyl)Phenyl]Propylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.