Description

1-(2-Tetrahydropyranyl)-1H-Pyrazole-4-Boronic Acid Pinacol Ester is a high-purity, protected boronic acid ester derivative, a crucial building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This advanced intermediate is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in constructing heterocyclic cores prevalent in medicinal chemistry.
• Agrochemical Research: Used to create new active ingredients for crop protection products through palladium-catalyzed cross-coupling methodologies.
• Material Science: Serves as a precursor for organic electronic materials, including polymers and small molecules for OLEDs or OFETs.
• Chemical Biology: Employed in the synthesis of probes and ligands for studying biological systems and target engagement.
• Catalyst & Ligand Development: Acts as a building block for creating novel organometallic catalysts and sophisticated ligand systems.
• Custom Synthesis & Contract Manufacturing: A critical reagent for CDMOs and fine chemical suppliers offering bespoke synthesis services.

Basic Information

Product Name	1-(2-Tetrahydropyranyl)-1H-Pyrazole-4-Boronic Acid Pinacol Ester
CAS No.	1003846-21-6
Molecular Formula	C14H23BN2O3
Molecular Weight	278.16 g/mol
Synonyms	1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-boronic acid pinacol ester; 1-(2-Tetrahydropyranyl)-1H-pyrazole-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole; THP-Protected Pyrazole-4-Boronic Ester; 1H-Pyrazole-4-boronic acid, 1-(tetrahydro-2H-pyran-2-yl)-, 1,1-dimethylethyl ester; Pyrazole boronic ester, THP-protected
EINECS	Contact for details

Quality Control

Our 1-(2-Tetrahydropyranyl)-1H-Pyrazole-4-Boronic Acid Pinacol Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized by advanced analytical techniques including NMR (1H, 13C, 11B), HPLC, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.