Description

1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrrolidin-2-One is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those requiring complex biaryl linkages.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a stable, air-tolerant boronic ester partner in palladium-catalyzed carbon-carbon bond formation reactions.
• Medicinal Chemistry Research: Enables the rapid exploration of structure-activity relationships (SAR) in drug discovery programs by providing a versatile handle for molecular diversification.
• Ligand and Material Science Precursor: Can be utilized in the synthesis of specialized ligands for catalysis or as a monomer for advanced polymeric materials.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for potential commercial APIs.

Basic Information

Item	Details
Product Name	1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrrolidin-2-One
CAS No.	1003309-09-8
Molecular Formula	C16H22BNO3
Molecular Weight	287.16 g/mol
Synonyms	1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidin-2-one; 2-(4-(2-Oxopyrrolidin-1-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-pyrrolidinone; 4-(2-Oxopyrrolidin-1-yl)phenylboronic acid pinacol ester; (4-(2-Oxopyrrolidin-1-yl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pyrrolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.