Description

3-Chloro-4-Hydroxy-5-Methoxyphenylboronicacid, Pinacol Ester is a high-purity, protected boronic acid derivative, a critical building block in modern synthetic chemistry. Its primary value lies in its enhanced stability compared to the free boronic acid, making it an indispensable reagent for Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing complex biaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific chlorinated phenolic frameworks.
• Material Science: Serves as a monomer or cross-linking agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile building block in academic and industrial R&D labs for exploring new carbon-carbon bond-forming methodologies.
• Ligand Synthesis: Used to prepare sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Diagnostic Reagent Development: Employed in the creation of molecular probes and sensors due to its specific reactive handle.

Basic Information

Product Name	3-Chloro-4-Hydroxy-5-Methoxyphenylboronicacid, Pinacol Ester
CAS No.	1003298-84-7
Molecular Formula	C13H18BClO4
Molecular Weight	284.54 g/mol
Synonyms	(3-Chloro-4-hydroxy-5-methoxyphenyl)boronic acid pinacol ester; 2-(3-Chloro-4-hydroxy-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chloro-4-hydroxy-5-methoxybenzeneboronic acid pinacol ester; Pinacol (3-chloro-4-hydroxy-5-methoxyphenyl)boronate; Boronic acid, B-(3-chloro-4-hydroxy-5-methoxyphenyl)-, 1,1-dimethylethyl ester (9CI); CAS 1003298-84-7
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Hydroxy-5-Methoxyphenylboronicacid, Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including cGMP intermediates for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.