Description

6-(Piperazin-1-Yl)Pyridin-3-Ylboronic Acid is a high-value boronic acid derivative and a crucial building block in modern pharmaceutical and agrochemical research. Its core value lies in its dual functionality, featuring a boronic acid group for Suzuki-Miyaura cross-coupling reactions and a piperazine-substituted pyridine scaffold that serves as a privileged structure in medicinal chemistry. This compound is essential for researchers and process chemists in the pharmaceutical industry developing new active pharmaceutical ingredients (APIs), particularly in oncology, CNS disorders, and infectious disease research.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small molecule drug candidates via palladium-catalyzed cross-coupling reactions.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linker-warhead conjugates for targeted protein degradation platforms.
• Agrochemical Synthesis: Intermediate for creating advanced crop protection agents with novel modes of action.
• Material Science Research: Precursor for synthesizing functional organic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Enables the creation of labeled compounds and activity-based probes for target identification and validation.
• Library Synthesis for High-Throughput Screening: Facilitates the rapid generation of diverse compound libraries for hit discovery.

Basic Information

Product Name	6-(Piperazin-1-Yl)Pyridin-3-Ylboronic Acid
CAS No.	1003043-67-1
Molecular Formula	C9H14BN3O2
Molecular Weight	207.04 g/mol
Synonyms	6-(Piperazin-1-yl)pyridine-3-boronic acid; 3-Borono-6-(1-piperazinyl)pyridine; 6-Piperazin-1-ylpyridine-3-boronic Acid; (6-(Piperazin-1-yl)pyridin-3-yl)boronic acid; 5-Borono-2-(1-piperazinyl)pyridine; 2-(Piperazin-1-yl)-5-pyridineboronic acid; Boronic acid, B-[6-(1-piperazinyl)-3-pyridinyl]-
EINECS	Contact for details

Quality Control

Our 6-(Piperazin-1-Yl)Pyridin-3-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and development use. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Anhydrous basis)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.