Description

3-(Iodomethyl)-1,1-Dimethoxycyclobutane is a specialized cyclobutane derivative functionalized with an iodomethyl group and protected as a dimethyl acetal. This compound matters as a versatile and reactive synthetic intermediate, offering chemists a unique handle for constructing complex molecular architectures via its reactive carbon-iodine bond and protected carbonyl equivalent. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications in medicinal chemistry, cross-coupling reactions, and polymer synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for cyclobutane-containing drug candidates.
• Cross-Coupling Reactions: Acts as an electrophilic coupling partner in palladium-catalyzed reactions (e.g., Negishi, Suzuki-Miyaura) for carbon-carbon bond formation.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and library synthesis to explore structure-activity relationships (SAR) around the cyclobutane scaffold.
• Agrochemical Synthesis: Employed in the research and development of new herbicides, fungicides, and insecticides with cyclobutane motifs.
• Advanced Material Precursor: Functions as a monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Organic Synthesis Reagent: Utilized in academic and industrial R&D for method development and the synthesis of complex natural products or fine chemicals.

Basic Information

Product Name	3-(Iodomethyl)-1,1-Dimethoxycyclobutane
CAS No.	1003013-83-9
Molecular Formula	C7H13IO2
Molecular Weight	256.08 g/mol
Synonyms	1,1-Dimethoxy-3-(iodomethyl)cyclobutane; 3-Iodomethyl-1,1-dimethoxycyclobutane; Cyclobutane, 3-(iodomethyl)-1,1-dimethoxy-; (Iodomethyl)dimethoxycyclobutane
EINECS	Contact for details

Quality Control

Our 3-(Iodomethyl)-1,1-Dimethoxycyclobutane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.