Description

1-(3-Bromophenyl)-2,2-Difluoroethanone is a high-purity, specialized aromatic ketone building block featuring both bromine and fluorine substituents. This compound is valued for its unique reactivity profile, enabling precise molecular construction in advanced synthetic pathways. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the difluoroacetyl and bromophenyl groups.
• Material Science Research: Serves as a precursor for synthesizing specialized monomers or ligands used in advanced polymers, liquid crystals, or metal-organic frameworks (MOFs).
• Fluorine Chemistry: An essential building block in medicinal chemistry for introducing fluorine atoms to improve metabolic stability, bioavailability, and binding affinity of target molecules.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex biaryl structures.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions in API manufacturing.

Basic Information

Item	Detail
Product Name	1-(3-Bromophenyl)-2,2-Difluoroethanone
CAS No.	1002356-02-6
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	3'-Bromo-2,2-difluoroacetophenone; 2,2-Difluoro-1-(3-bromophenyl)ethanone; 1-(3-Bromophenyl)-2,2-difluoroethan-1-one; 3-Bromophenyldifluoromethyl ketone; α,α-Difluoro-3-bromoacetophenone; (3-Bromophenyl)difluoromethyl ketone; 3-Bromo-α,α-difluoroacetophenone
EINECS	Contact for details

Quality Control

Our 1-(3-Bromophenyl)-2,2-Difluoroethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation to ensure it meets the stringent requirements for research and process chemistry. Certificates of Analysis (COA) with lot-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.