Description

1-Phenyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, heterocyclic boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient carbon-carbon and carbon-heteroatom bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process R&D teams developing novel active pharmaceutical ingredients (APIs), agrochemicals, and functional organic materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in kinase inhibitor and heterocyclic compound libraries.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides with enhanced efficacy.
• Material Science: Precursor for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport layers.
• Chemical Biology: Employed in the synthesis of molecular probes and bioconjugates for target identification and validation.
• Catalyst Ligand Synthesis: Serves as a starting material for preparing sophisticated ligand systems used in homogeneous catalysis.
• Academic & Contract Research: Fundamental reagent for methodological development in cross-coupling and borylation chemistry within R&D laboratories.

Basic Information

Product Name	1-Phenyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1002334-13-5
Molecular Formula	C₁₅H₁₉BN₂O₂
Molecular Weight	270.14 g/mol
Synonyms	1-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-Phenyl-1H-pyrazole-3-boronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-phenyl-1H-pyrazole; 1-Phenyl-3-(pinacolboryl)-1H-pyrazole; Pyrazole-3-boronic acid pinacol ester, 1-phenyl-; 1-Phenyl-1H-pyrazol-3-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 1-Phenyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), residual solvent content, and confirmation of structure. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.