Description

1-Phenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon and carbon-heteroatom bond formation via the versatile Suzuki-Miyaura cross-coupling reaction. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures. Its CAS number is 1002334-12-4.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing pyrazole and biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl-pyrazole structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of drug candidates through targeted library synthesis and structure-activity relationship (SAR) studies.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl linkages with high efficiency and functional group tolerance.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing novel bidentate or polydentate ligands for transition metal catalysis.

Basic Information

Product Name	1-Phenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1002334-12-4
Molecular Formula	C₁₅H₁₉BN₂O₂
Molecular Weight	270.14 g/mol
Synonyms	1-Phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-phenyl-1H-pyrazole; 1-Phenyl-4-(pinacolatoboryl)-1H-pyrazole; 1-Phenyl-1H-pyrazole-4-boronic acid pinacol ester; Pyrazole-4-boronic acid pinacol ester, 1-phenyl-; 1002334-12-4; 1-Phenyl-4-(pinacolboranyl)-1H-pyrazole
EINECS	Contact for details

Quality Control

Our 1-Phenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for demanding research and scale-up applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize decomposition. Recommended storage temperature: 2-8°C (refrigerated) for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.