Description

1-Methyl-3-Phenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value organoboron building block, specifically a pyrazole-substituted pinacol boronic ester, widely used in modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon and carbon-heteroatom bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced material synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing pyrazole and biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where precise molecular design is critical.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heteroaryl linkages efficiently.
• Chemical Biology & Medicinal Chemistry: Utilized in the discovery and optimization of bioactive compounds for target identification and lead optimization studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for the custom synthesis of complex, proprietary molecules on a commercial scale.

Basic Information

Product Name	1-Methyl-3-Phenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1002334-06-6
Molecular Formula	C₁₆H₂₁BN₂O₂
Molecular Weight	284.16 g/mol
Synonyms	1-Methyl-3-phenyl-1H-pyrazole-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-3-phenyl-1H-pyrazole; 1-Methyl-3-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 3-Phenyl-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; Pyrazole boronic ester pinacol; CAS 1002334-06-6
EINECS	Contact for details

Quality Control

Every batch of our 1-Methyl-3-Phenyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by NMR and HPLC are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.