Description

3-(4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Phenyl)Propanoic Acid is a specialized diazirine-based photoaffinity labeling reagent. This compound matters for its ability to form highly reactive carbene intermediates upon photolysis, enabling the covalent cross-linking and study of biomolecular interactions. It is primarily needed by researchers and manufacturers in pharmaceutical development, chemical biology, and proteomics for target identification and mechanism-of-action studies.

Application

• Photoaffinity Labeling (PAL): A critical tool for mapping small molecule-protein binding sites and identifying unknown biological targets in drug discovery.
• Chemical Proteomics: Used to create activity-based probes for profiling enzyme families and studying protein function in complex biological systems.
• Bioconjugation & Linker Chemistry: The carboxylic acid moiety allows for conjugation to amines, alcohols, or other functional groups, serving as a versatile linker in probe synthesis.
• Material Science Research: Potential application in surface functionalization and the development of photo-crosslinkable polymers or coatings.
• Metabolic Pathway Analysis: Can be incorporated into substrate analogs to trap and identify enzymes involved in specific metabolic processes.

Basic Information

Product Name	3-(4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Phenyl)Propanoic Acid
CAS No.	1002328-44-0
Molecular Formula	C₁₁H₉F₃N₂O₂
Molecular Weight	258.20 g/mol
Synonyms	3-[4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]phenyl]propanoic acid; 3-(4-(3-(Trifluoromethyl)diazirin-3-yl)phenyl)propionic Acid; TPD-PA; 3-(p-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid; Photoaffinity Labeling Reagent 1002328-44-0; Diazirine-based Crosslinker; Trifluoromethylphenyl Diazirine Propanoic Acid
EINECS	Contact for details

Quality Control

Our 3-(4-(3-(Trifluoromethyl)-3H-Diazirin-3-Yl)Phenyl)Propanoic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may compromise its reactivity and stability. For long-term storage, consider storing under an inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, and common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.