Description

2-(4-(1,1-Difluoroethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound is a critical intermediate in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to accelerate the discovery and production of novel active ingredients.

Application

This specialized boronic ester is a versatile reagent designed for precision synthesis. Key application areas include:

• Suzuki-Miyaura Cross-Coupling Reactions: As a key coupling partner for the synthesis of biaryl and heterobiaryl structures, which are core motifs in many pharmaceuticals and agrochemicals.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for constructing fluorinated aromatic segments to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Employed in creating novel herbicides, fungicides, and insecticides where the difluoroethylphenyl moiety imparts desirable biological activity.
• Material Science Research: Serves as a monomer or precursor in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Medicinal Chemistry: Utilized for the synthesis of molecular probes and tool compounds for target identification and validation.
• Process Chemistry & Scale-up: Provides a reliable and consistent building block for the transition from laboratory-scale discovery to pilot and commercial manufacturing.

Basic Information

Product Name	2-(4-(1,1-Difluoroethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1000994-94-4
Molecular Formula	C14H19BF2O2
Molecular Weight	268.11 g/mol
Synonyms	4-(1,1-Difluoroethyl)benzeneboronic acid pinacol ester; 4-(1,1-Difluoroethyl)phenylboronic acid pinacol ester; [4-(1,1-Difluoroethyl)phenyl]boronic acid pinacol ester; 2-[4-(1,1-Difluoroethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-(1,1-Difluoroethyl)phenyl)boronic acid pinacol ester; 1,1-Difluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethane; Pinacol [4-(1,1-difluoroethyl)phenyl]boronate
EINECS	Contact for details

Quality Control

Our 2-(4-(1,1-Difluoroethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. All products undergo rigorous analytical testing, including NMR (1H, 13C, 19F, 11B) and HPLC analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.