Description

1-(Cyclopropylmethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-purity boronic ester derivative, a crucial building block in modern synthetic chemistry. Its value lies in enabling efficient cross-coupling reactions, such as Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing pyrazole and cyclopropyl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of advanced polymers and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester group makes it a stable and versatile reagent for palladium-catalyzed carbon-carbon bond formation.
• Medicinal Chemistry: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space.
• Chemical Biology: Used as a probe or linker in bioconjugation and the development of chemical tools.

Basic Information

Product Name	1-(Cyclopropylmethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1000801-75-1
Molecular Formula	C13H21BN2O2
Molecular Weight	248.13 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(cyclopropylmethyl)-1H-pyrazole; 1-(Cyclopropylmethyl)-1H-pyrazole-4-boronic acid pinacol ester; 1-(Cyclopropylmethyl)pyrazole-4-boronic acid pinacol ester; 1-Cyclopropylmethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole, 1-(cyclopropylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1000801-75-1
EINECS	Contact for details

Quality Control

Our 1-(Cyclopropylmethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.