Description

2,6-Dibromo-4-(trifluoromethoxy)iodobenzene is a highly functionalized halogenated benzene derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring bromine, iodine, and a trifluoromethoxy group, makes it a versatile and valuable building block for constructing complex molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science: Serves as a precursor for organic electronic materials, liquid crystals, and specialty polymers where halogen and fluorine substituents modify electronic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Stille, Negishi) due to the presence of both bromine and iodine leaving groups, allowing for sequential functionalization.
• Fluorine Chemistry: The trifluoromethoxy (OCF3) group is a valuable motif for improving metabolic stability and lipophilicity in drug design, making this compound a key synthon.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for client-specific custom synthesis projects requiring complex, multi-halogenated aromatic cores.

Basic Information

Product Name	2,6-Dibromo-4-(trifluoromethoxy)iodobenzene
CAS No.	1000578-22-2
Molecular Formula	C7H2Br2F3IO
Molecular Weight	469.80 g/mol
Synonyms	1,3-Dibromo-5-iodo-2-(trifluoromethoxy)benzene; 4-Iodo-2,6-dibromo-1-(trifluoromethoxy)benzene; 2,6-Dibromo-4-iodophenyl trifluoromethyl ether; Benzene, 2,6-dibromo-4-iodo-1-(trifluoromethoxy)-; 1-Iodo-3,5-dibromo-4-(trifluoromethoxy)benzene; 2,6-Dibromo-4-iodo-α,α,α-trifluoroanisole
EINECS	Contact for details

Quality Control

Our 2,6-Dibromo-4-(trifluoromethoxy)iodobenzene is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maximize shelf-life stability. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.