Description

5-Bromo-4-Chloro-2-Iodotoluene is a high-purity halogenated toluene derivative, a crucial building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides multiple reactive sites for selective functionalization and cross-coupling reactions. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the halogen atoms influence biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi couplings due to the presence of iodine and bromine, enabling sequential functionalization.
• Chemical Library Development: Employed in medicinal chemistry for the parallel synthesis of diverse compound libraries for high-throughput screening.
• Ligand and Catalyst Preparation: Used to synthesize complex ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	5-Bromo-4-Chloro-2-Iodotoluene
CAS No.	1000578-03-9
Molecular Formula	C7H5BrClI
Molecular Weight	331.38 g/mol
Synonyms	1-Bromo-2-chloro-5-iodo-4-methylbenzene; 2-Iodo-5-bromo-4-chlorotoluene; 4-Chloro-5-bromo-2-iodotoluene; Toluene, 5-bromo-4-chloro-2-iodo-; 5-Bromo-4-chloro-2-iodo-1-methylbenzene; 2-Bromo-1-chloro-4-iodo-5-methylbenzene (alternate numbering)
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Chloro-2-Iodotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.