Description

1,2-Dibromo-3-Chloro-5-Fluorobenzene is a high-purity, multi-halogenated benzene derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an invaluable intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists working in medicinal chemistry, material science, and the production of specialty chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where halogenated aromatic cores are required.
• Material Science: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to its reactive halogen sites.
• Chemical Research: Employed in academic and industrial laboratories for method development and exploring new reaction pathways in halogenated arene chemistry.
• Ligand and Catalyst Preparation: Used to synthesize complex chelating ligands and organocatalysts.

Basic Information

Product Name	1,2-Dibromo-3-Chloro-5-Fluorobenzene
CAS No.	1000577-62-7
Molecular Formula	C6H2Br2ClF
Molecular Weight	308.24 g/mol
Synonyms	1,2-Dibromo-3-chloro-5-fluorobenzene; 3-Chloro-1,2-dibromo-5-fluorobenzene; 5-Fluoro-1,2-dibromo-3-chlorobenzene; 1,2-Dibromo-3-chloro-5-fluoro-benzene; Benzene, 1,2-dibromo-3-chloro-5-fluoro-; DBFCB (common abbreviation)
EINECS	Contact for details

Quality Control

Our 1,2-Dibromo-3-Chloro-5-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.