Description

2-Bromo-4-(Difluoromethoxy)-1-Iodobenzene is a high-value halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, iodine, and a difluoromethoxy group, makes it a versatile precursor for constructing complex molecules, particularly in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty agrochemicals where the introduction of fluorine and halogens is critical for modulating biological activity and physical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic cores essential in the manufacture of advanced display and electronic materials.
• Cross-Coupling Reactions: The bromine and iodine substituents offer orthogonal reactivity for sequential Suzuki, Stille, and Sonogashira cross-coupling reactions to create complex biaryl systems.
• Fluorine Chemistry Exploration: An important substrate for studying the effects of the difluoromethoxy moiety on electronic properties and lipophilicity in molecular design.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of tailored intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	2-Bromo-4-(Difluoromethoxy)-1-Iodobenzene
CAS No.	1000575-02-9
Molecular Formula	C7H4BrF2IO
Molecular Weight	348.91 g/mol
Synonyms	1-Bromo-2-(difluoromethoxy)-5-iodobenzene; 2-Bromo-1-iodo-4-(difluoromethoxy)benzene; Benzene, 2-bromo-1-iodo-4-(difluoromethoxy)-; 4-Bromo-3-(difluoromethoxy)iodobenzene; 5-Bromo-2-(difluoromethoxy)iodobenzene; 2-Bromo-4-difluoromethoxy-1-iodobenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(Difluoromethoxy)-1-Iodobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data including HPLC purity, NMR (1H, 13C, 19F), and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available for every batch and supplied with each order to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.