Description

1-Bromo-4-Chloro-2,3-Difluorobenzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty agrochemicals where precise halogen positioning is required for bioactivity and material properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for fluorine-containing drugs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoro motif enhances lipophilicity and metabolic stability.
• Liquid Crystal Materials (LCM): Serves as a core intermediate for manufacturing fluorinated liquid crystals used in advanced display technologies (LCDs).
• Organic Electronic Materials: Employed in the research and production of organic semiconductors, OLED materials, and photovoltaic materials.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Stille, and Buchwald-Hartwig amination reactions to introduce the halogenated phenyl group into complex molecules.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	1-Bromo-4-Chloro-2,3-Difluorobenzene
CAS No.	1000574-47-9
Molecular Formula	C6H2BrClF2
Molecular Weight	227.44 g/mol
Synonyms	2,3-Difluoro-4-chloro-1-bromobenzene; 4-Bromo-1-chloro-2,3-difluorobenzene; 1-Chloro-4-bromo-2,3-difluorobenzene; Benzene, 1-bromo-4-chloro-2,3-difluoro-; 2,3-Difluoro-1-bromo-4-chlorobenzene; 4-Chloro-1-bromo-2,3-difluorobenzene; 1-Bromo-4-chloro-2,3-difluorobenzol
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Chloro-2,3-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures material consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.