Description

4-Chloro-3,5-Difluorophenylacetonitrile is a versatile and high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated structure enables precise molecular modifications. It is primarily sought after by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging the fluorine atoms for enhanced bioactivity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays.
• Functional Polymer Building Block: Incorporated into specialty polymers to impart specific chemical resistance, thermal stability, or optical properties.
• Organic Light-Emitting Diodes (OLEDs): Acts as an intermediate in the production of electron-transport or host materials for OLED devices.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new reactions and creating novel chemical entities.

Basic Information

Product Name	4-Chloro-3,5-Difluorophenylacetonitrile
CAS No.	1000540-50-0
Molecular Formula	C8H4ClF2N
Molecular Weight	187.57 g/mol
Synonyms	(4-Chloro-3,5-difluorophenyl)acetonitrile; 2-(4-Chloro-3,5-difluorophenyl)acetonitrile; 4-Chloro-3,5-difluorobenzeneacetonitrile; α-Cyano-4-chloro-3,5-difluorotoluene; 4-Chloro-3,5-difluoro-benzeneacetonitrile; 4-Chloro-3,5-difluorophenyl cyanomethyl; 1000540-50-0; 4-Chloro-3,5-difluorophenylacetonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-3,5-Difluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and strong oxidizing agents. The container must be kept tightly closed in a dry and well-ventilated place due to its light-sensitive nature.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.