Description

1H-Indole-1-Carboxylic Acid, 2-Borono-7-Chloro-, 1-(1,1-Dimethylethyl) Ester is a high-value, multi-functional boronic acid ester derivative of indole, designed for advanced synthetic chemistry. This compound serves as a critical key intermediate and building block in the development of complex molecules, particularly in pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester functional group makes it an essential reagent for forming carbon-carbon bonds, a fundamental step in constructing complex organic frameworks.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the indole scaffold for biological activity.
• Material Science & Chemical Biology: Employed in the creation of advanced organic materials and as a molecular probe in biochemical studies.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for optimizing and scaling the production of target active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1H-Indole-1-Carboxylic Acid, 2-Borono-7-Chloro-, 1-(1,1-Dimethylethyl) Ester
CAS No.	1000068-24-5
Molecular Formula	C₁₄H₁₇BClNO₄
Molecular Weight	309.55 g/mol
Synonyms	2-Borono-7-chloro-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; 7-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 7-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 7-Chloro-1-(tert-butoxycarbonyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole; BOC-protected 7-chloro-2-boronoindole pinacol ester; Boronic acid ester intermediate CAS 1000068-24-5
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, NMR, and LC-MS to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. Our quality management system supports the stringent requirements of cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) in a desiccator for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.