Description

D-Proline, 3-Ethenyl-1-Methyl-, Methyl Ester, (3R)-Rel- (9Ci) is a non-natural, chiral proline derivative characterized by its specific stereochemistry and functional groups. This compound serves as a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in asymmetric synthesis, medicinal chemistry, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of active pharmaceutical ingredients (APIs), especially for complex molecules targeting neurological and metabolic disorders.
• Medicinal Chemistry Research: Used in the design and synthesis of novel drug candidates, leveraging its rigid proline scaffold to influence peptide conformation and receptor binding.
• Asymmetric Catalysis: Potential application as a precursor for chiral ligands or organocatalysts used in enantioselective transformations.
• Peptidomimetics Development: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and biological activity.
• Agrochemical Synthesis: Intermediate in the research and production of chiral agrochemicals, such as herbicides and fungicides.
• Academic & Industrial R&D: Serves as a standard or starting material in chemical research exploring new synthetic methodologies and structure-activity relationships.

Basic Information

Product Name	D-Proline, 3-Ethenyl-1-Methyl-, Methyl Ester, (3R)-Rel- (9Ci)
CAS No.	199917-93-6
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	(3R)-rel-3-Ethenyl-1-methyl-D-proline methyl ester; Methyl (3R)-rel-3-ethenyl-1-methyl-D-prolinate; (R)-1-Methyl-3-vinylproline methyl ester; D-1-Methyl-3-vinylproline methyl ester; 3-Vinyl-1-methyl-D-proline methyl ester; (3R)-1-Methyl-3-vinylpyrrolidine-2-carboxylic acid methyl ester; Proline, 3-ethenyl-1-methyl-, methyl ester, (3R)-rel- (9CI)
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and enantiomeric purity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.