Description

2-Nitro-1H-Imidazole-1-Acetic Acid 2,3,5,6-Tetrafluorophenyl Ester is a high-purity, specialized chemical intermediate designed for advanced synthesis. This compound is valued for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs) and diagnostic agents. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and life science sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of nitroimidazole-based pharmaceuticals, including potential radiosensitizers and antimicrobial agents.
• Proteomics Research: Used as an activated ester for bioconjugation and labeling of biomolecules, such as proteins and peptides, in biochemical assays.
• Radiopharmaceuticals: Serves as a versatile synthon for developing novel PET (Positron Emission Tomography) and SPECT (Single-Photon Emission Computed Tomography) imaging tracers.
• Agrochemical Synthesis: Employed in the research and development of new crop protection agents and herbicides.
• Material Science: Acts as a monomer or cross-linking agent in the creation of specialty polymers with unique electronic or binding properties.
• Chemical Biology: Utilized for activity-based protein profiling (ABPP) and the development of chemical probes to study enzyme function.

Basic Information

Product Name	2-Nitro-1H-Imidazole-1-Acetic Acid 2,3,5,6-Tetrafluorophenyl Ester
CAS No.	199734-70-8
Molecular Formula	C11H5F4N3O4
Molecular Weight	307.17 g/mol
Synonyms	2,3,5,6-Tetrafluorophenyl 2-Nitro-1H-imidazole-1-acetate; 1H-Imidazole-1-acetic acid, 2-nitro-, 2,3,5,6-tetrafluorophenyl ester; 2-Nitroimidazole-1-acetic acid tetrafluorophenyl ester; Tetrafluorophenyl 2-nitroimidazolylacetate; Activated 2-Nitroimidazole Ester; 2-Nitro-1-imidazoleacetic Acid Pentafluorophenyl Ester (common misnomer); TFP Ester of 2-Nitroimidazole-1-acetic Acid
EINECS	Contact for details

Quality Control

Our 2-Nitro-1H-Imidazole-1-Acetic Acid 2,3,5,6-Tetrafluorophenyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support regulatory filings with detailed documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.