Description

7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of the tetrahydroisoquinoline scaffold and the electron-withdrawing trifluoromethyl group, which is crucial for modulating the physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the CF₃ group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for nitrogen-containing ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic electronic materials.
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research into the effects of fluorination on molecular properties.
• Custom Synthesis & Contract Manufacturing: A high-purity starting material for bespoke chemical manufacturing and scale-up projects.

Basic Information

Product Name	7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	199678-32-5
Molecular Formula	C₁₀H₁₀F₃N
Molecular Weight	201.19 g/mol
Synonyms	7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-7-(trifluoromethyl)isoquinoline; 7-Trifluoromethyl-1,2,3,4-tetrahydroisoquinoline; 7-CF3-THIQ; 7-(Trifluoromethyl)THIQ; 7-Trifluoromethyltetrahydroisoquinoline; 199678-32-5
EINECS	Contact for details

Quality Control

Our 7-(Trifluoromethyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorinating agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.