Description

(S)-(+)-Nalpha-Benzyl-Nbeta-Boc-L-Hydrazinoalanine Dicyclohexylamine Salt is a high-purity, non-natural amino acid derivative designed for advanced pharmaceutical research and peptide synthesis. This compound serves as a critical chiral building block, enabling the controlled introduction of a hydrazinoalanine moiety into peptide chains, which is essential for developing novel therapeutic agents and biochemical probes. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical R&D for creating peptide-based drugs, enzyme inhibitors, and specialized bioconjugates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide therapeutics and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the unique hydrazinoalanine functionality.
• Bioconjugation & Linker Chemistry: Serves as a specialized building block for creating peptide-drug conjugates (PDCs) and other bioconjugation platforms due to its reactive hydrazine group.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new bioactive peptide sequences.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) containing modified amino acids.
• Biochemical Tool Development: Facilitates the creation of specialized probes and ligands for studying enzyme mechanisms and protein interactions.

Basic Information

Product Name	(S)-(+)-Nalpha-Benzyl-Nbeta-Boc-L-Hydrazinoalanine Dicyclohexylamine Salt
CAS No.	199605-10-2
Molecular Formula	C26H44N4O4
Molecular Weight	476.66 g/mol
Synonyms	(S)-Nα-Benzyl-Nβ-(tert-butoxycarbonyl)-L-hydrazinoalanine dicyclohexylamine salt; (S)-(+)-Nα-Bzl-Nβ-Boc-L-hydrazinoalanine·DCHA salt; Boc-NH-NH-CH(CH2C6H5)-CH(NH2)-COOH · DCHA; (S)-2-Amino-3-(benzyl((tert-butoxycarbonyl)hydrazinyl))propanoic acid dicyclohexylamine salt; L-Hydrazinoalanine, Nα-benzyl-Nβ-Boc-, dicyclohexylamine salt, (S)-; Boc-Hydrazinoalanine(Bzl)-OH · DCHA; 199605-10-2
EINECS	Contact for details

Quality Control

Our (S)-(+)-Nalpha-Benzyl-Nbeta-Boc-L-Hydrazinoalanine Dicyclohexylamine Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.