Description

4',5'-Difluoro-2'-Hydroxyacetophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical precursor in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industries requiring the synthesis of fluorinated active pharmaceutical ingredients (APIs), advanced materials, and specialty fine chemicals will find this material essential for their research and development pipelines.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel, fluorinated pesticides and herbicides, where fluorine atoms can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and advanced organic materials with tailored properties.
• Ligand and Catalyst Development: Employed in the creation of novel chelating ligands and organocatalysts for asymmetric synthesis.
• Fluorescent Probe Synthesis: Utilized as a starting material for constructing fluorophores and molecular probes used in bioimaging and diagnostics.
• Academic & Industrial R&D: A versatile reagent for method development and exploratory chemistry in university and corporate research laboratories.

Basic Information

Product Name	4',5'-Difluoro-2'-Hydroxyacetophenone
CAS No.	199586-38-4
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	1-(2-Hydroxy-4,5-difluorophenyl)ethan-1-one; 2'-Hydroxy-4',5'-difluoroacetophenone; 4,5-Difluoro-2-hydroxyacetophenone; 2-Acetyl-4,5-difluorophenol; 1-(4,5-Difluoro-2-hydroxyphenyl)ethanone; Difluoro Hydroxyacetophenone
EINECS	Contact for details

Quality Control

Our 4',5'-Difluoro-2'-Hydroxyacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.