Description

n-Boc-2-Amino-5-Bromobenzaldehyde is a high-purity, protected aromatic aldehyde building block of significant importance in synthetic organic chemistry. Its core value lies in providing a versatile and reactive handle for constructing complex heterocyclic and pharmaceutical intermediates while protecting the amine functionality. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality raw materials for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing benzimidazole, quinazoline, or other fused heterocyclic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the bromo and aldehyde groups allow for selective derivatization.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and photoactive polymers due to its conjugated aromatic system.
• Peptidomimetics and PROTACs: The protected amine and aldehyde functionality make it suitable for constructing linkers and molecular glues in targeted protein degradation research.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses (CROs/CMOs) serving the global life sciences industry.

Basic Information

Product Name	n-Boc-2-Amino-5-Bromobenzaldehyde
CAS No.	199273-16-0
Molecular Formula	C12H14BrNO3
Molecular Weight	300.15 g/mol
Synonyms	5-Bromo-2-[(tert-butoxycarbonyl)amino]benzaldehyde; 2-((tert-Butoxycarbonyl)amino)-5-bromobenzaldehyde; tert-Butyl (5-bromo-2-formylphenyl)carbamate; 2-Amino-5-bromobenzaldehyde N-Boc protected; Boc-2-Abz(5-Br)-CHO; (5-Bromo-2-formylphenyl)carbamic acid tert-butyl ester; N-Boc-2-amino-5-bromobenzaldehyde
EINECS	Contact for details

Quality Control

Our n-Boc-2-Amino-5-Bromobenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for demanding research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.