Description

n-(tert-Butoxycarbonyl)-2-Nitrobenzenesulfonamide is a specialized chemical intermediate featuring both a nitrobenzenesulfonamide (Nosyl) protecting group and a tert-butoxycarbonyl (Boc) protecting group. This dual functionality makes it a valuable reagent in multi-step synthetic sequences, particularly in the pharmaceutical and agrochemical sectors. It is primarily used by research chemists and process development scientists for the selective protection and deprotection of amines, enabling the precise construction of complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing amine functionalities.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide chemistry for the orthogonal protection of amino groups.
• Agrochemical Research: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex heterocycles and natural product analogs.
• Protecting Group Chemistry: Facilitates selective reactions by temporarily masking reactive amine sites during synthetic transformations.
• Process Chemistry Development: Used to develop scalable and efficient manufacturing routes for target molecules in pilot plants.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-2-Nitrobenzenesulfonamide
CAS No.	198572-71-3
Molecular Formula	C11H14N2O6S
Molecular Weight	302.30 g/mol
Synonyms	Boc-2-Nitrobenzenesulfonamide; N-Boc-2-nitrobenzenesulfonamide; tert-Butyl (2-nitrophenylsulfonyl)carbamate; 2-Nitro-N-[(2-methyl-2-propanyl)oxycarbonyl]benzenesulfonamide; N-(tert-Butoxycarbonyl)-2-nitrobenzenesulfonamide; N-Boc-Nosylamide; Boc-Nosyl-NH2
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)-2-Nitrobenzenesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.