Description

Boc-Beta,β-Dimethyl-D-Cys(Pmebzl)-Oh is a high-purity, protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing the unique, sterically hindered beta,β-dimethyl-D-cysteine residue into peptide chains, which can significantly enhance metabolic stability and conformational rigidity. It is an essential building block for pharmaceutical researchers and peptide manufacturers developing novel therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Pharmaceutical Intermediate: Key raw material in the synthesis of complex therapeutic peptides targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic Drug Design: Used to create conformationally constrained peptide analogs with improved bioavailability and receptor selectivity.
• Research & Development: Serves as a critical reagent in academic and industrial R&D for studying structure-activity relationships (SAR) in peptide science.
• API Synthesis: Building block in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) that require non-proteinogenic, modified cysteine derivatives.
• Bioconjugation Chemistry: Potential use in creating peptide-drug conjugates or peptide-based diagnostic agents due to its protected thiol side chain.

Basic Information

Product Name	Boc-Beta,β-Dimethyl-D-Cys(Pmebzl)-Oh
CAS No.	198470-36-9
Molecular Formula	C19H29NO4S
Molecular Weight	367.50 g/mol
Synonyms	(2R)-3-[(4-Methoxybenzyl)sulfanyl]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-2-methylpropanoic acid; Boc-D-β,β-Dimethylcysteine(Pmb)-OH; tert-Butyloxycarbonyl-D-β,β-dimethylcysteine(4-methoxybenzyl) ester; Boc-D-β,β-Dimethyl-Cys(PMB)-OH; N-(tert-Butoxycarbonyl)-3-[(4-methoxybenzyl)thio]-D-β,β-dimethylalanine; Boc-D-β,β-Me2Cys(PMBzl)-OH
EINECS	Contact for details

Quality Control

Our Boc-Beta,β-Dimethyl-D-Cys(Pmebzl)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.