Description

3-(Trifluoromethoxy)Iodobenzene is a high-value fluorinated aromatic building block characterized by its trifluoromethoxy and iodine substituents. This compound is essential for introducing the metabolically stable trifluoromethoxy group into target molecules, significantly enhancing their lipophilicity and biological activity. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced synthetic applications, including cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethoxy group improves compound stability and efficacy.
• Material Science Precursor: Serves as a monomer or building block for advanced materials, such as liquid crystals and organic semiconductors.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution in organic molecules and for synthesizing fluorinated analogs.
• Chemical Synthesis: Employed in nucleophilic substitution and metal-halogen exchange reactions to construct diverse chemical libraries.

Basic Information

Product Name	3-(Trifluoromethoxy)Iodobenzene
CAS No.	198206-33-6
Molecular Formula	C7H4F3IO
Molecular Weight	287.01 g/mol
Synonyms	1-Iodo-3-(trifluoromethoxy)benzene; 3-Iodophenyl trifluoromethyl ether; m-(Trifluoromethoxy)iodobenzene; 3-Trifluoromethoxy-1-iodobenzene; (3-Iodophenyl)(trifluoromethyl) ether; Benzene, 1-iodo-3-(trifluoromethoxy)-; 3-Iodo-alpha,alpha,α-trifluoroanisole
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethoxy)Iodobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality assurance ensures reliable performance in your most sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.