Description

m-Peg4-Aldehyde is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive aldehyde group at one terminus and a methoxy-capped tetraethylene glycol chain at the other. This compound is a crucial building block in bioconjugation and pharmaceutical development, enabling the site-specific modification of biomolecules like proteins and peptides. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and advanced material science for creating stable, functionalized conjugates.

Application

• Bioconjugation Linker: Used for the site-specific PEGylation of proteins, peptides, and antibodies via reductive amination with primary amines, improving pharmacokinetics and stability.
• Drug Delivery Systems: Serves as a functional spacer arm in the synthesis of antibody-drug conjugates (ADCs) and targeted nanoparticle formulations.
• Surface Functionalization: Enables the covalent attachment of biomolecules to sensor chips, microarrays, and other solid supports for diagnostic and research applications.
• Hydrogel and Biomaterial Synthesis: Acts as a cross-linking agent or functional monomer in the creation of biocompatible hydrogels and polymeric scaffolds for tissue engineering.
• Chemical Probe Development: Utilized to synthesize affinity probes, fluorescent tags, and other molecular tools for biological imaging and assay development.

Basic Information

Product Name	m-Peg4-Aldehyde
CAS No.	197513-96-5
Molecular Formula	C13H26O7
Molecular Weight	294.34 g/mol
Synonyms	mPEG4-CHO; Methoxy-PEG4-aldehyde; α-Methoxy-ω-aldehyde-pentaethylene glycol; 2,5,8,11-Tetraoxatridecan-13-al; 3,6,9,12-Tetraoxatetradecanal, 14-methoxy-; Ald-mPEG4; m-PEG4-Butyraldehyde; O-(2-(2-(2-(2-Methoxyethoxy)ethoxy)ethoxy)ethyl)butyraldehyde
EINECS	Contact for details

Quality Control

Our m-Peg4-Aldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and critical impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. The material is easily oxidized and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.